Mouse lung regeneration after H1N1
- Correspondence to Dr Imran Mahmud, Oxford University Clinical Academic Graduate School, Hertford College, University of Oxford, OX1 3BW, UK; imran.mahmud{at}medsci.ox.ac.uk
This study demonstrates that following an ARDS-like syndrome in mice secondary to infection with a murine-adapted H1N1 virus, complete recovery follows the emergence of a population of stem cells bearing the differentiation markers of alveoli.
Contrary to the existing bleomycin-based models of pulmonary injury causing fibrosis, this murine H1N1 model sustains substantial airway damage and epithelial destruction, followed by …
