Endothelial cells as regulators of cytokine storms during influenza infection
- Correspondence to Dr M Gautam, ST6 Respiratory Medicine, University Hospital of Aintree, Liverpool, UK;
The morbidity and mortality of severe influenza infections has been attributed to excessive inflammatory cytokine production and early innate immune cell recruitment. This study highlights the pulmonary endothelium as a central regulator of the cytokine storm, in particular demonstrating the role of the sphingosine-1-phosphate (S1P1) signalling system.
S1P1 receptor specific agonists were shown to significantly reduce …