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- Cystic fibrosis
- paediatric lung disease
- airway remodelling
- endobronchial biopsy
- asthma
- bronchoscopy
- innate immunity
- paediatric lung disease
- paediatric physician
- respiratory infection
- viral infection
- airway epithelium
- allergic lung disease
- asthma mechanisms
- COPD exacerbations
- COPD pathology
- histology/cytology
- paediatric asthma
- bacterial infection
We thank Burgel and colleagues for their valuable comments.1 We agree that a cautious approach should be adopted when considering the use of bronchoscopy and biopsy in cystic fibrosis (CF) research. As stated in our review article,2 we have confirmed the safety of endobronchial biopsy in children and infants with CF. Reassuringly, we have encountered no complications even in children with advanced lung disease. We advocate the use of endobronchial biopsy to investigate mechanisms of airway remodelling events and their relationship to infection and inflammation in children, but claim no experience of bronchoscopy in adult CF. It would be inappropriate for us to comment on the role of bronchoscopy in adults.
Footnotes
Linked article 200824.
Competing interests None.
Provenance and peer review Not commissioned; internally peer reviewed.