Particulate allergens aggravate allergic asthma in mice
- Correspondence to Dr A Jeyabalan, Specialist Registrar, University Hospitals Bristol NHS Trust, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK; abiramyjeyabalan{at}hotmail.com
Ambient inhalable particulate matter acts as an efficient carrier of allergens allowing penetration deep into the distal airways. Epidemiological studies have shown an association between the increased incidence of asthma and levels of ambient particulate matter from air pollutants. Most experimental models investigating the pathogenesis of allergic asthma have used soluble allergens (sAgs) whereas knowledge …
