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Respiratory muscles, exercise and ventilation
S115 The effect of posture on the 2nd intercostal space surface parasternal electromyogram (EMGpara): validating a novel clinical tool to measure neural respiratory drive
  1. M C Ramsay1,
  2. E-S Suh1,
  3. S Mandal2,
  4. P Murphy1,
  5. J Steier2,
  6. A Simonds3,
  7. N Hart4
  1. 1Department of Asthma, Allergy and Respiratory Science, Division of Asthma, Allergy and Lung Biology, King's College London, London, UK
  2. 2Lane Fox Respiratory Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK
  3. 3National Heart and Lung Institute, Respiratory Biomedical Research Unit, Royal Brompton Hospital and Imperial College London, London, UK
  4. 4Guy's and St Thomas' NHS Foundation Trust and King's College London, National Institute of Health Research Comprehensive Biomedical Research Centre, London, UK

Abstract

Introduction Although neural respiratory drive (NRD), as measured by diaphragm EMG, has been shown to reflect the balance between the respiratory muscle load and capacity providing a marker of disease severity, it requires insertion of an oesophageal catheter which limits its clinical utility. 2nd intercostal space surface EMGpara has been shown to be a useful alternative non-invasive monitoring tool in acute COPD (Murphy et al. Thorax 2011;66:602–8) and overnight in asthmatic patients (Steier et al. Thorax 2011;66:609–14). Previous data has suggested that there is reduced activation of the chest wall muscles in normal subjects in the supine posture as a consequence of a change in chest wall configuration. To assess the clinical utility and validity of EMGpara to continuously monitor changes in NRD, we investigated the effect of different posture on the EMGpara in normal subjects.

Methods Wet gel electrodes were placed at the parasternal edge of the 2nd intercostal space following skin preparation. Signals were amplified and filtered before analogue to digital conversion and digital processing providing the raw signal and root mean squared data. Five positions included sitting at 45 degrees, lying flat, lying on the right and left hand side and sitting at 90 degrees. EMGpara was measured during 2 min of tidal breathing in each posture. Resting EMG signal was normalised to the maximal inspiratory manoeuvres performed in each position (EMGpara%max).

Results Eight healthy subjects were recruited with a mean age 32 years ±2 years; 4 male; BMI 23±2 kg/m2. Mean EMGpara%max was 4.60±3.93% sitting at 45 degrees, 4.82±2.27% lying flat, 5.32±3.91% lying on the right hand side, 4.47±4.47% lying on the left hand side, 4.58±3.75% sitting at 90 degrees. A repeated measures ANOVA showed there was no significant difference in EMGpara%max between the different postures (p= 0.97; Abstract S115 figure 1).

Abstract S115 Figure 1

Box and whisker Plot. Reference position is 45 degrees. There was no difference lying flat (p=0.9), lying on the right hand side (RHS; p=0.7), lying on the left hand side (LHS; p=0.9) and with 90 degrees upright (p=1.0).

Conclusion NRD, as measured by EMGpara%max, is stable across a range of different postures. It provides comparable information independent of body position and could be considered as a monitoring tool in clinical practice, including for overnight monitoring.

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