Article Text

PDF

Acute and chronic respiratory infections
P248 Associations of depression, fatigue and quality of life in adult non-CF bronchiectasis
  1. H Batchelor,
  2. S Brill,
  3. J S Brown,
  4. J R Hurst
  1. UCL Medical School, London, UK

Abstract

Introduction Non-cystic fibrosis bronchiectasis is a chronic lung condition characterised by persistent cough, excessive sputum and recurrent chest infections. Symptoms also include dyspnoea, haemoptysis, depression and fatigue. The latter can have a major impact on patients' physical and psychosocial well-being. We investigated disease- and patient-related factors associated with quality of life, fatigue and depression in bronchiectasis.

Method Patients were recruited from the London Bronchiectasis Cohort. A clinical diagnosis of bronchiectasis was confirmed by review of previous CT imaging. A full medical history including exacerbations and aetiology, spirometry, and the SGRQ (for quality of life), CESD (depression), and FACIT (fatigue) questionnaires were completed at a baseline appointment. Statistics were analysed using SPSS.

Results 31 patients (25 female) were studied with a mean (SD) age of 58.8 (SD 12.0) years. The commonest aetiologies were post-infectious (15/31) and idiopathic (11/31). The median (IQR) self-reported exacerbation frequency was 3.0 (1.9–5.6)/year.

Frequent exacerbations were associated with poorer quality of life: there was a significant association between exacerbation frequency and the SGRQ score (r=0.46, p=0.013). Frequent exacerbations were also associated with greater baseline breathlessness (r=0.40, p=0.038), but not with lung function, depression or fatigue. Patients with greater disease severity (lower FEV1) also had more breathlessness (MRC: r=−0.38, p=0.046), and poorer quality of life (SGRQ: r=−0.50, p=0.005) but not greater depression or fatigue. The depression scale was not related to any of the disease or patient-related factors. The only patient or disease-related variable associated with fatigue was breathlessness (MRC: r=−0.57, p=0.002).

Conclusion The determinants of quality of life, depression and fatigue in non-CF bronchiectasis are different. Depression in this population appears to be independent of markers of disease severity such as FEV1, exacerbation frequency and MRC dyspnoea score.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.