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  • A comparison between interferon gamma release assays and the tuberculin skin test in the contact tracing of patients with chronic kidney disease

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Letter to the Editor
A comparison between interferon gamma release assays and the tuberculin skin test in the contact tracing of patients with chronic kidney disease
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  1. D W Connell1,
  2. A Singanayagam1,
  3. R Charif2,
  4. P M George1,
  5. P L Molyneaux1,
  6. C McCrudden1,
  7. M Magtoto1,
  8. E Harden3,
  9. S L Seneviratne3,
  10. N D Duncan2,
  11. O M Kon1
  1. 1TB Service, Imperial College Healthcare NHS Trust, London, UK
  2. 2West London Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
  3. 3Department of Immunology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK
  1. Correspondence to Dr David W Connell, Department of Chest and Allergy, St. Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, London, W2 1NY, UK; d.connell{at}imperial.ac.uk

https://doi.org/10.1136/thx.2010.149088

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    We welcome the recent guidelines from the British Thoracic Society on the management of Mycobacterium tuberculosis infection and disease in patients with chronic kidney disease (CKD).1 We note the paucity of evidence (particularly from the UK) in this population regarding the use of interferon gamma release assays (IGRA) in screening patients for latent tuberculosis infection (LTBI).

    We present data to show the first UK-based cohort comparing the tuberculin skin test (TST) and the two commercially available IGRA—T-SPOT.TB (Oxford Immunotec, Abingdon, UK) and Quantiferon-Gold-in-Tube (Cellestis, Carnegie, Australia)—in a population of inpatients with CKD. It involves the follow-up of 61 patients from a renal inpatient ward who were screened …

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      Authors' response
      Heather Milburn Neil Ashman Peter Davies
      Thorax 2010; 66 730-730 Published Online First: 14 Oct 2010. doi: 10.1136/thx.2010.150102