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Thorax 66:473 doi:10.1136/thx.2010.149898
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A role for cigarette fumes in the development of emphysema through reduced alveolar cell proliferation and upregulation of apoptosis

  1. M East
  1. Correspondence to M East, AcFY2, Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Old Medical School, Leeds General Infirmary, Great George Street, West Yorkshire, UK; m.east{at}doctors.net.uk

This paper describes a molecular mechanism for the loss of alveolar tissue in cigarette smoke-induced lung injury. Under the influence of adverse environmental conditions including hypoxia, the intracellular stress protein Rtp801 is transcribed. This study sought to demonstrate that Rtp801 downregulates the kinase mammalian target of …


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