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Thorax 66:1096 doi:10.1136/thx.2010.157941
  • PostScript
  • Correspondence

Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?

  1. Christopher Ward1
  1. 1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
  2. 2Department of Respiratory Paediatrics, Great North Children's Hospital, Newcastle upon Tyne, UK
  3. 3Cardiopulmonary Transplantation Unit, Freeman Hospital, Newcastle upon Tyne, UK
  1. Correspondence to Dr Malcolm Brodlie, c/o Paediatric Respiratory Secretaries, Old Children's Outpatients Department, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; m.j.brodlie{at}ncl.ac.uk
  • Accepted 4 January 2011
  • Published Online First 15 March 2011

We read with interest the recent paper by Facco et al which showed that Th17 cells are present in blood, bronchoalveolar lavage (BAL) and lung tissue from people with sarcoidosis. The authors conclude that Th17 cells are involved in the pathogenesis of sarcoidosis as a multisystem disorder.1

Interestingly, the paper mentions expression of interleukin (IL)-17 protein by macrophages. Currently, a strong emphasis exists in the literature …


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