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Correspondence
Sarcoidosis is a Th1/Th17 multisystem disorder: wider implications
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  1. C A Parisinos
  1. Gastrointestinal Unit, Western General Hospital, Edinburgh, UK
  1. Correspondence to Constantinos A Parisinos, Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; c.a.parisinos{at}doctors.org.uk

https://doi.org/10.1136/thoraxjnl-2011-200290

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    Facco et al demonstrated elevated levels of T helper 17 (Th17) cells in the peripheral blood and in the bronchoalveolar lavage of patients with active sarcoidosis; increased expression of interleukin 17 (IL-17) and IL-23R in lung and lymph node specimens was also noted.1 These results suggest a role for the IL-23/Th17 inflammatory axis in the pathogenesis of sarcoidosis.

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      Monica Facco Gianpietro Semenzato Carlo Agostini
      Thorax 2011; 66 1012-1012 Published Online First: 08 Jun 2011. doi: 10.1136/thoraxjnl-2011-200387