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P144 HEALTH-RELATED QUALITY OF LIFE IN OBESITY HYPOVENTILATION SYNDROME (OHS) PRIOR TO INITIATION OF HOME MECHANICAL VENTILATION (HMV)
1P. Murphy, 1K. Brignall, 1A. Williams, 1C. Davidson, 2M. Hind, 2A. Simonds, 3J. Moxham, 2M. Polkey, 4N. Hart. 1Lane Fox Respiratory Unit, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, 2Sleep and Ventilation Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK, 3Department of Thoracic Medicine, King’s College Hospital, London, UK, 4Guy’s and St Thomas’ NHS Foundation Trust and King’s College London NIHR Biomedical Research Centre, London, UK
Introduction With the rising incidence of obesity, we have observed a significant increase in obesity related respiratory problems such as obesity hypoventilation syndrome (OHS). Patients with obesity-related respiratory problems can present electively with chronic respiratory failure (CRF) or as an emergency with acute on CRF. The aim of this study was to investigate differences in illness perception and health-related quality of life (HRQL) in OHS patients presenting electively or as an emergency.
Method Consecutive patients initiated on HMV at two tertiary referral centres were recruited. Baseline anthropometrics and HRQL, using severe respiratory insufficiency questionnaire (SRI), were measured.
Results Twenty-five patients were enrolled. Nine patients started HMV following acute decompensation and 16 were initiated electively. As expected, those patients presenting acutely had more pronounced hypercapnia than the group initiated on HMV electively. However, despite less severe physiological gas exchange derangement and with similar lung volumes, elective patients had a trend to more severe self-assessed impairment of HRQL scores compared with the patients presenting acutely. This trend to more severe impairment reached significance in 2/5 subscales, those relating to attendant symptoms and sleep (AS) and social relationships (SR). The difference between groups tended to significance (p = 0.09) in the well-being subscale (WB) (table 1).
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Conclusion These data show the high symptom burden in patients with OHS and suggest that …