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Thorax 64:763-769 doi:10.1136/thx.2008.110916
  • Asthma

Adverse effects of salmeterol in asthma: a neuronal perspective

Table 1

Baseline patient characteristics

Patient no Age Sex Years since diagnosis PC20 (mg/ml) FEV1 (% pred) Allergies β2-Receptor polymorphisms
arg16gly gln27glu
1 20 M 13 4.0 91.9 P, D, A Gly/Gly Gln/Gln
2 19 M 5 3.8 81.8 D, A Gly/Gly Glu/Glu
3 20 M 8 4.5 105.7 P, D Arg/Gly Gln/Gln
4 18 M 5 0.2 84.2 P Arg/Gly Gln/Glu
5 36 F 5 5.0 103.6 P, D, A Gly/Gly Gln/Glu
6 19 F 11 3.3 102.2 P, D, A Gly/Gly Gln/Gln
7 39 F 6 4.2 86.8 P, A Arg/Arg Gln/Gln
8 20 F 10 3.8 109.1 P, D Arg/Gly Gln/Glu
9 42 F 10 5.5 115.3 P Arg/Gly Gln/Glu
10 44 M 8 0.4 82.5 D Arg/Gly Gln/Glu
11 18 M 3 2.8 95.8 P Gly/Gly Glu/Glu
12 29 M 3 5.5 88.7 P, A Gly/Gly Glu/Glu
13 18 M 6 0.8 89.9 D, A Arg/Gly Gln/Gln
14 38 M 28 0.8 92.0 P, D Arg/Gly Gln/Glu
15 26 F 10 1.5 93.2 P, D Arg/Gly Gln/Glu
16 19 M 10 1.4 97.3 P, D, A Gly/Gly Glu/Glu
17 19 F 8 8.0 87.0 P, D, A Arg/Gly Gln/Glu
18 20 F 15 2.7 106.0 P Arg/Gly Gln/Glu
Median 20 8 3.6 92.6
  • A, animal hair; Arg, arginine; D, house dust mite; F, female; FEV1, forced expiratory volume in 1 s as a percentage of the predicted value (% pred); Gln, glutamine; Glu, glutamic acid; Gly, glycine; M, male; P, pollen; PC20, provocative concentration of histamine causing a 20% fall in FEV1.

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