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Thorax 64:671-676 doi:10.1136/thx.2008.108290
  • Airway biology

Granulocyte–macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD

Table 3 Group 3: clinical characteristics and GM-CSF/GM-CSFR expression in proximal airway from lung resection
Normal Smoker COPD
Number 8 11 10
Age* 58 (3) 60 (3) 66 (3)
Male/female 7/1 8/3 7/3
Never/current/ex-smokers 6/0/2 0/0/11 0/0/10
Pack-years* 0 (1) 30 (7) 39 (6)
FEV1* 2.8 (0.2) 2.6 (0.2) 1.8 (0.2)
FEV1, % predicted* 87 (3) 87 (4) 64 (4)
Pre-BD FEV1/FVC* 79 (3) 81 (4) 55 (3)
GM-CSF
Submucosa† 0.5 (1) 0.8 (2.4) 0.2 (1.1)
ASM† 0 (0) 0 (0.1) 0 (0)
GM-CSFR
Submucosa† 2.3 (6.1) 0.3 (1.3) 0.5 (4.4)
ASM† 0 (0.1) 0 (0) 0 (0)

  • *Mean (SE). †Median (interquartile range).

  • ASM, airway smooth muscle; BD, bronchodilator; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory voume in 1 s; FVC, forced vital capacity; GM-CSF, granulocyte–macrophage colony-stimulating factor; GM-CSFR, granulocyte–macrophage colony-stimulating factor receptor; PC, provocation concentration.

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