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Thorax 64:467-475 doi:10.1136/thx.2008.107946
  • Interstitial lung disease

Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis

Table 1 Demographic and spirometric characteristics of patients with idiopathic interstitial pneumonia and control subjects
Characteristics IPF/UIP(n = 25) COP/OP(n = 20) NSIP(n = 20) Control(n = 20)
Sex (M/F) 18/7 12/8 11/9 10/10
Age (years) 65 (43–72) 50 (38–62) 60 (41–68) 36 (29–60)
Smokers/non-smokers 21/4 7/13 12/8 13/7
FVC (% predicted) 66 (3)* 78 (4)* 71 (3)* 101 (12)
TLC (% predicted) 58 (4)* 77 (3)* 69 (4)* 99 (11)
Tlco (% predicted) 48 (6)* 68 (5)* 61 (4)* 88 (6)
  • Values expressed as mean (SD) and age as median (range).

  • *Statistical significance between disease groups and control group assessed with t test (p<0.001).

  • COP, cryptogenic organising pneumonia; FVC, forced vital capacity; IPF, interstitial pulmonary fibrosis; NSIP, non-specific interstitial pneumonia; OP, organising pneumonia; TLC, total lung capacity; Tlco, lung carbon monoxide transfer factor; UIP, usual interstitial pneumonia.

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