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Thorax 2009;64:192-196 doi:10.1136/thx.2007.094912
  • Lung cancer
    • 1507

Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence

  1. J-J Hung1,2,3,
  2. W-H Hsu3,
  3. C-C Hsieh3,
  4. B-S Huang3,
  5. M-H Huang3,
  6. J-S Liu2,
  7. Y-C Wu3
  1. 1
    Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
  2. 2
    Department of Surgery, Cathay General Hospital and School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
  3. 3
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, Taiwan
  1. Dr Y-C Wu, Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, No 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan; wuyc{at}vghtpe.gov.tw
  • Received 18 December 2007
  • Accepted 24 August 2008

Abstract

Objective: Resection is the best treatment for patients with stage I non-small cell lung cancer (NSCLC). Patterns of disease recurrence after complete resection in stage I NSCLC have not been well demonstrated. The aim of this study was to evaluate the prognostic predictors of post-recurrence survival in patients with resected stage I NSCLC with local recurrence.

Methods: The clinicopathological characteristics of 123 patients with local recurrence after complete resection of stage I NSCLC in Taipei Veterans General Hospital between 1980 and 2000 were retrospectively reviewed. Post-recurrence survival and their predictors were analysed.

Results: The patterns of local recurrence included local only in 74 (60.2%) and both local and distant in 49 (39.8%) patients. The 1 and 2 year post-recurrence survival rates for the 74 patients with local only recurrence were 48.7% and 17.6%, respectively. Tumour size (p = 0.033) and treatment for initial recurrence (p<0.001) were significant predictors for post-recurrence survival in 74 patients with local only recurrence in univariate analyses. The hazard of death was greater in patients with larger tumour size. Treatment for initial recurrence (p = 0.001) was still a significant prognostic indicator in multivariate analyses. Patients who underwent reoperation after local recurrence survived longer than those who received chemotherapy and/or radiotherapy and those that received no treatment.

Conclusions: Treatment for initial recurrence is a prognostic predictor for post-recurrence survival in resected stage I NSCLC with local recurrence. Complete surgical resection should be considered in selected candidates with resectable local recurrent disease.

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