Obesity, waist size and prevalence of current asthma in the California Teachers Study cohort
- J Von Behren1,
- M Lipsett2,
- P L Horn-Ross1,3,
- R J Delfino4,
- F Gilliland5,
- R McConnell5,
- L Bernstein6,
- C A Clarke1,3,
- P Reynolds1,3
- 1Northern California Cancer Center, Berkeley and Fremont, California, USA
- 2Environmental Health Investigations Branch, California Department of Public Health, Richmond, California, USA
- 3Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
- 4Department of Epidemiology, School of Medicine, University of California, Irvine, California, USA
- 5Keck School of Medicine, University of Southern California, Los Angeles, California, USA
- 6Department of Cancer Etiology, City of Hope National Medical Center, Duarte, California, USA
- Correspondence to Ms J Von Behren, Northern California Cancer Center, 2001 Center Street, Suite 700, Berkeley, CA 94704, USA;
- Received 29 January 2009
- Accepted 6 July 2009
- Published Online First 25 August 2009
Background: Obesity is a risk factor for asthma, particularly in women, but few cohort studies have evaluated abdominal obesity which reflects metabolic differences in visceral fat known to influence systemic inflammation. A study was undertaken to examine the relationship between the prevalence of asthma and measures of abdominal obesity and adult weight gain in addition to body mass index (BMI) in a large cohort of female teachers.
Methods: Prevalence odds ratios (ORs) for current asthma were calculated using multivariable linear modelling, adjusting for age, smoking and race/ethnicity.
Results: Of the 88 304 women in the analyses, 13% (n = 11 500) were obese (BMI ⩾30 kg/m2) at baseline; 1334 were extremely obese (BMI ⩾40 kg/m2). Compared with those of normal weight, the adjusted OR for adult-onset asthma increased from 1.40 (95% confidence interval (CI) 1.31 to 1.49) for overweight women to 3.30 (95% CI 2.85 to 3.82) for extremely obese women. Large waist circumference (>88 cm) was associated with increased asthma prevalence, even among women with a normal BMI (OR 1.37, 95% CI 1.18 to 1.59). Among obese women the OR for asthma was greater in those who were also abdominally obese than in women whose waist was ⩽88 cm (2.36 vs 1.57). Obese and overweight women were at greater risk of severe asthma episodes, measured by urgent medical visits and hospital admissions.
Conclusions: This study confirms the association between excess weight and asthma severity and prevalence, and showed that a large waist was associated with increased asthma prevalence even among women considered to have normal body weight.
Funding National Cancer Institute (R01 CA77398, R01 CA105224).
Competing interests None.
Provenance and Peer review Not commissioned; not externally peer reviewed.
Ethics approval The use of human subject data was approved by the California Committee for the Protection of Human Subjects and the institutional review boards of the participating institutions.