Genome-wide transcriptional profiling linked to social class in asthma
- 1University of British Columbia, Department of Psychology, Vancouver, British Columbia, Canada
- 2UCLA, Department of Medicine, Division of Hematology–Oncology, Los Angeles, California, USA
- 3UCLA AIDS Institute, UCLA Molecular Biology Institute, Los Angeles, California, USA
- 4UCLA Norman Cousins Center, Los Angeles, California, USA
- Dr E Chen, University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver BC V6T1Z4, Canada;
- Received 20 December 2007
- Accepted 4 August 2008
- Published Online First 10 November 2008
Objectives: Low socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. This study tested whether the social environment could get “under the skin” to alter genomic activity in children with asthma.
Design and participants: Two group design of children with physician diagnosed asthma who came from low or high SES families.
Outcomes: Genome-wide transcriptional profiles from T lymphocytes of children with asthma.
Results: Children with asthma from a low SES background showed overexpression of genes regulating inflammatory processes, including those involved in chemokine activity, stress responses and wound responses, compared with children with asthma from a high SES background. Bioinformatic analysis suggested that decreased activity of cyclic AMP response element binding protein and nuclear factor Y and increased nuclear factor κB transcriptional signalling mediated these effects. These pathways are known to regulate catecholamine and inflammatory signalling in immune cells.
Conclusions: This study provides the first evidence in a sample of paediatric patients diagnosed with asthma that the larger social environment can affect processes at the genomic level. Specifically, gene transcription control pathways that regulate inflammation and catecholamine signalling were found to vary by SES in children with asthma. Because these pathways are the primary targets of many asthma medications, these findings suggest that the larger social environment may alter molecular mechanisms that have implications for the efficacy of asthma therapeutics.
▸ Additional methodological data are published online only at http://thorax.bmj.com/content/vol64/issue1
Funding: This study was supported by NIH grant HL073975 and the Canadian Institutes of Health Research.
Competing interests: None.
Ethics approval: Ethics approval was obtained.