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S133 BETA CRYPTOXANTHIN LEVELS CORRELATE WITH LUNG FUNCTION IN MIDDLE-AGED MEN
1KM McClean, 2JS Elborn, 2F Kee, 2J Woodside, 2IS Young. 1Royal Victoria Hospital, Belfast, UK, 2Queen’s University, Belfast, UK
Background: Beta cryptoxanthin is one of the pro-vitamin A carotenoids and is found in many yellow/orange fruits and vegetables. It is known to be an antioxidant and is reported to be a good biomarker of fruit and vegetable intake. We hypothesised that levels of serum beta cryptoxanthin would be related to FEV1.
Methods: From 1991 to 1994, 2745 men aged 50–59 years were recruited into the Belfast arm of the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 2010 of these men were rescreened at 10 years. In this study we describe the cross-sectional analysis of the 1208 men who had a valid spirometry trace (ERS/ATS criteria) and plasma sample at follow-up. Beta cryptoxanthin levels were measured using HPLC analysis. FEV1 values at 10 years were modelled using simple linear regression, and adjusted for age, height, body mass index, smoking history, cholesterol level and social status.
Results: The men had a mean age of 64.4 years and 36.9% had never smoked. Serum beta cryptoxanthin levels were positively correlated with FEV1 (r = 0.23, n = 1208, p<0.001). In the crude analysis, for each nanomole per litre increment in serum beta cryptoxanthin levels, FEV1 was 2.22 ml greater (95% CI 1.60 to 2.75). Following adjustment for covariates, for each nanomole per litre increment in serum beta cryptoxanthin levels, FEV1 was 1.26 ml greater (95% CI 0.78 to 1.75, p<0.001).
Conclusion: Serum beta cryptoxanthin levels are positively correlated with FEV1 in this cohort of middle-aged men from Northern Ireland. This suggests that in this population a moderate increase in serum beta cryptoxanthin levels (achievable by a modest increase in dietary intake …