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We acknowledge the proposition raised by Dr Rose that a comparison of nicotine replacement therapy (NRT) and varenicline using equal pre-cessation treatment regimens may result in different efficacy outcomes from those found in our trial. However, we would like to reiterate that our open-label comparison of varenicline with NRT was a pragmatic trial based on current treatment regimen recommendations by the manufacturers of the products and in accordance with current recommendations for transdermal NRT use in established health guidelines.1 2
Dr Rose suggests that the imbalance in pre-cessation treatment between products in our trial reflects a flaw in the design of our study. The objective of this study was to compare …