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Lung alert
Miscellaneous
Lysophosphatidic acid is an important mediator of fibroblast recruitment in IPF
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  1. Ian Scott
  1. Dr I Scott, Wrightington Hospital, Hall Lane, Appley Bridge, Wigan, Lancashire WN6 9EP, UK; ian.c.scott{at}btinternet.com

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    Lysophosphatidic acid (LPA) and its G protein-coupled receptor (LPA1) play key pathogenic roles in idiopathic pulmonary fibrosis (IPF). Previous research has highlighted the importance of fibroblast chemoattractant activity in the lungs in patients with IPF. New findings suggest the LPA-LPA1 pathway has a pivotal role in mediating fibroblast migration and vascular leakage in …

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