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Twins with severe recurrent chest infections

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CLINICAL PRESENTATION

Two homozygotic twins were delivered at 31 weeks of gestational age by caesarean section, with birth weight 1490 and 1710 g, respectively. The family history was unremarkable. Their mother received steroid prophylaxis for hyaline membrane disease. They showed no perinatal problems. By the age of 8 months both had recurrent spells of respiratory distress, possibly triggered by viral infections, characterised by cough, fever, wheezing, …

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