Renal impairment following aminoglycoside therapy in cystic fibrosis
- Dr A Tai, Department of Respiratory Medicine, Royal Children’s Hospital Melbourne, Victoria 3052, Australia; andrew.tai{at}rch.org.au
- Accepted 8 July 2008
Cystic fibrosis (CF) is a chronic respiratory, life limiting illness in the Caucasian population. Chronic infection with Pseudomonas aeruginosa occurs in more than 80% of adults and this contributes to deterioration in lung function over time.1 A reported long term complication includes renal impairment from presumed cumulative aminoglycoside antibiotics. Aminoglycosides are highly effective against Pseudomonas aeruginosa and effectively penetrate the sputum of patients with CF, achieving more effective bacterial killing.2 The nephrotoxicity of aminoglycosides is reported to …
