Association between asthma and serum adiponectin concentration in women
- 1University of New Mexico Health Sciences Center School of Medicine, Albuquerque, New Mexico, USA
- 2University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
- 3University of Minnesota, Minneapolis, Minnesota, USA
- 4The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
- 5University of Minnesota, Minneapolis, Minnesota, USA (also affiliated with the University of Oslo, Oslo, Norway)
- Dr A Sood, Division of Pulmonary and Critical Care Medicine, University of New Mexico Health Sciences Center School of Medicine, Department of Medicine, 1 University of New Mexico, Albuquerque, NM 87131, USA;
- Received 19 September 2007
- Accepted 16 March 2008
- Published Online First 4 April 2008
Background: The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese subjects. A study was undertaken to examine whether the serum adiponectin concentration is associated with human asthma and whether it explains the association between adiposity and asthma, particularly in women and in premenopausal women.
Methods: A cross-sectional analysis was performed of 2890 eligible subjects at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort and its YALTA ancillary study who had either current asthma or never asthma at that evaluation. Obesity was defined as body mass index (BMI) ⩾30 kg/m2. Multivariable logistic regression analysis was performed with current asthma status as the dependent variable.
Results: Women, but not men, with current asthma had a lower mean unadjusted serum adiponectin concentration than those with never asthma (p<0.001; p for sex interaction <0.001). Similarly, current asthma was related to obesity only in women (OR 3.31, 95% CI 2.00 to 5.46, p for sex interaction = 0.004); this association was little affected by adjusting for serum adiponectin. The prevalence of current asthma in premenopausal women was reduced in the highest compared with the lowest tertile of serum adiponectin concentration (OR 0.46, 95% CI 0.26 to 0.84, p = 0.03), after adjusting for BMI. However, the interaction between serum adiponectin concentration and BMI category on current asthma status was not significant in premenopausal women or women overall.
Conclusions: A high serum adiponectin concentration may protect against current asthma in premenopausal women but does not explain the association between asthma and adiposity.
Funding: AS is supported by the University of New Mexico Clinical Translational Science Center Scholar Award and DHHS/NIH/NCRR/GCRC Grant # 5M01 RR00997; WSB is supported by ES01247; MWS has several grants/contracts from NIDDK, NHLBI and NICHD. The Coronary Artery Risk Development in Young Adults Study is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the Coronary Artery Risk Development in Young Adults Study Investigators.
Competing interests: None.
Ethics approval: This study was approved by the University of New Mexico Human Research Review Committee, Albuquerque, NM, USA.