Incidence and characteristics of viral community-acquired pneumonia in adults
- L C Jennings1,2,
- T P Anderson1,
- K A Beynon1,
- A Chua1,
- R T R Laing3,
- A M Werno1,2,
- S A Young1,
- S T Chambers2,
- D R Murdoch1,2
- 1Canterbury Health Laboratories, Christchurch, New Zealand
- 2Department of Pathology, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
- 3Canterbury Respiratory Research Group, University of Otago, Christchurch, New Zealand
- Dr L C Jennings, Canterbury Health Laboratories, P O Box 151, Christchurch, New Zealand;
- Received 21 November 2006
- Accepted 22 May 2007
- Published Online First 15 June 2007
Background: In adults, viral causes of community-acquired pneumonia (CAP) are poorly characterised. The aims of this study were to characterise the viral aetiology of CAP in adults by using an extensive array of viral diagnostic tests and to compare the characteristics of viral pneumonia with those of pneumococcal pneumonia.
Methods: Adults admitted to Christchurch Hospital over a 1-year period with CAP were included in the study. Microbiological testing methods included blood and sputum cultures, urinary antigen testing for Streptococcus pneumoniae and Legionella pneumophila, antibody detection in paired sera and detection of respiratory viruses in nasopharyngeal swabs by immunofluorescence, culture and PCR.
Results: Of 304 patients with CAP, a viral diagnosis was made in 88 (29%), with rhinoviruses and influenza A being the most common. Two or more pathogens were detected in 49 (16%) patients, 45 of whom had mixed viral and bacterial infections. There were no reliable clinical predictors of viral pneumonia, although several variables were independently associated with some aetiologies. The presence of myalgia was associated with pneumonia caused by any respiratory virus (OR 3.62, 95% CI 1.29 to 10.12) and influenza pneumonia (OR 190.72, 95% CI 3.68 to 9891.91). Mixed rhinovirus/pneumococcal infection was associated with severe disease.
Conclusions: Virus-associated CAP is common in adults. Polymicrobial infections involving bacterial and viral pathogens are frequent and may be associated with severe pneumonia.
Funding: Health Research Council of New Zealand, the Canterbury Respiratory Research Trust and Canterbury District Health Board.
Competing interests: None.