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Thorax 2007;62:779
  • Miscellaneous

Severe infantile lower respiratory tract illness may be characterised by a reduced, rather than increased, immune response

  1. J Carter
  1. Senior House Officer, University Hospital of North Tees, Teesside; jeicarter@hotmail.com

    ▴ Welliver T, Garofalo R, Hosakote Y, et al. Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. J Infect Dis2007;195:1126–36.

    The pathogenesis of severe infantile respiratory illness due to respiratory syncytial virus (RSV) and influenza virus is not fully understood. Some evidence suggests there is an increased T lymphocyte and cytokine response to infection. However, this cross-sectional study found otherwise. …

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