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Thorax 2007;62:535
  • Miscellaneous

Using molecular markers as a means of predicting prognosis and outcomes in the treatment of lung cancer

  1. Jenny Cosgrove
  1. Senior House Officer, Mater Infirmorum Hospital, Belfast; jenny.c@doctors.org.uk

    ▴ Zheng Z, Chen T, Li X. DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. NEJM2007;356:800–08.

    This study evaluated the potential association between the expression of two specific proteins and treatment outcomes of patients with early non-small-cell lung cancer.

    Increased expression of the gene RRM1 (regulatory subunit of ribonucleotide reductase) has been shown to reduce metastases, inhibit development of lung tumours and prolong survival. Similar data have been shown for ERCC1 (excision repair …

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