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Early growth and adult respiratory function in men and women followed from the fetal period to adulthood
  1. Dexter Canoy1,
  2. Juha Pekkanen3,
  3. Paul Elliott2,
  4. Anneli Pouta4,
  5. Jaana Laitinen6,
  6. Anna-Liisa Hartikainen5,
  7. Paavo Zitting1,
  8. Swatee Patel7,
  9. Mark P Little2,
  10. Marjo-Riitta Järvelin2
  1. 1Department of Public Health Science and General Practice, University of Oulu, Finland
  2. 2Department of Epidemiology and Public Health, Imperial College London, UK
  3. 3Environmental Epidemiology Unit, National Public Health Institute, Finland
  4. 4Department of Child and Adolescent Health, National Public Health Institute, Finland
  5. 5Department of Obstetrics and Gynecology, University of Oulu, Finland
  6. 6Oulu Regional Institute of Occupational Health, Finland
  7. 7School of Computing and Mathematical Sciences, The University of Greenwich, UK
  1. Correspondence to:
    Dr Dexter Canoy
    Northwest Institute for Bio-Health Informatics, The University of Manchester, Oxford Road, Manchester M13 9PT, UK; dexter.canoy{at}manchester.ac.uk

Abstract

Background: While some studies suggest that poor fetal growth rate, as indicated by lower birth weight, is associated with poor respiratory function in childhood, findings among adults remain inconsistent. A study was undertaken to determine the association between early growth and adult respiratory function.

Methods: A longitudinal birth cohort study was performed of 5390 men and women born full term and prospectively followed from the fetal period to adulthood. Weight at birth and infancy were recorded, and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were assessed by standard spirometry at age 31 years.

Results: Adult FEV1 and FVC increased linearly with higher birth weight in both men and women with no apparent threshold. After adjustment for sex, adult height and other potential confounders operating through the life course, every 500 g higher birth weight was associated with a higher FEV1 of 53.1 ml (95% CI 38.4 to 67.7) and higher FVC of 52.5 ml (95% CI 35.5 to 69.4). These positive associations persisted across categories of smoking, physical activity and body mass index, with the lowest respiratory function noted among those with lower birth weight who were smokers, led a sedentary lifestyle or were overweight. Weight gain in infancy was also positively associated with adult lung function.

Conclusion: Birth weight is continuously and independently associated with adult respiratory function. It is plausible that poor growth in early life may restrict normal lung growth and development, which could have long-term consequences on lung function later in life.

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Children born with lower birth weight tend to have poorer lung function than those of higher birth weight,1–4 although longitudinal data assessing the relation between birth weight and adult lung function are limited and findings have been conflicting.5,6,7,8,9,10,11,12,13,14 The apparent inconsistencies could be due to small sample sizes, biases associated with the retrospective collection of birth weight data, high proportion of persons lost to follow-up or lack of information on potential confounders and mediating factors that may operate through the life course.

As poor lung function in adulthood is consistently shown as an independent predictor of all-cause mortality and deaths due to respiratory and cardiovascular diseases,15,16 identifying whether the influence of lower birth weight on impaired respiratory function extends to adulthood could have important clinical and public health implications. We examined the relation between birth weight as a marker of general fetal growth, growth in infancy and subsequent adult respiratory function assessed at age 31 years in a large population-based cohort of men and women prospectively followed from the fetal period to adulthood.

METHODS

Participants and data collection

Recruitment and data collection of the 1966 Northern Finland Birth Cohort (NFBC) have been described elsewhere.17 Briefly, the original birth cohort consisted of offspring (n = 12 058 live births with birth weight ⩾600 g, 94.5% born at ⩾37 gestational weeks) of all pregnant women in Northern Finland with expected deliveries in 1966. Women were recruited and baseline data were collected by questionnaire during routine prenatal health check at maternity health centres, with about 80% visiting the centres for the first time by the 16th gestational week. The course of the pregnancy and data on birth at the time of delivery (99% in hospitals) were prospectively recorded. Growth data of the offspring were collected at approximately 1 year of age from child welfare centres which have been established as part of the comprehensive welfare health system in Finland since 1944.18 Data on hospital admissions were obtained from hospital records and from the national hospital discharge register. Follow-up in 1997–8 consisted of questionnaires sent to all cohort members, as well as clinical examination of those living in Northern Finland or in the capital city area.19 The University of Oulu ethics committee approved the study and participants gave written informed consent.

Early life variables

Birth weight (to the nearest 10 g) was measured immediately after birth. Gestational age at birth was computed as number of completed weeks from date of mother’s last menstrual period to delivery. Weight was also measured around 12 months of age (mean 12.3, range 10–14 months); the weight gain during the first year was calculated by subtracting the birth weight from this value.

Mothers were classified as smokers if they smoked at least one cigarette per day during pregnancy, quitters if they smoked at any time during 12 months preceding but not during pregnancy, and non-smokers if they neither smoked from 12 months preceding nor during pregnancy. Prenatal social class was based on father’s occupation (I = professionals, II = skilled workers, III = unskilled workers, and IV = farmers) or mother’s occupation if missing. Using International Classification of Diseases (ICD) 8th edition, we identified children admitted to hospitals with diagnoses of acute respiratory illness or pneumonia occurring up to age 7 years as, at these ages, respiratory infection has been associated with reduced adult respiratory function.20 We also identified participants who had physician-diagnosed asthma at age 14 years assessed from questionnaires sent to participants and parents in 1980.

Adult variables

In 1997, 97% (n = 11 637) of the cohort were alive, 7.4% of whom (n = 856) were living abroad and 0.8% (n = 96) were untraceable. In 1997–8, those living in Northern Finland or the Helsinki area (n = 8463) were invited to a clinical examination conducted by trained nurses using a standardised procedure. Respiratory function was assessed by forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) using a Vitalograph P-model spirometer (Vitalograph Ltd, Buckingham, UK) with a volumetric accuracy of ±2% or ±50 ml, whichever was greater. The spirometer was calibrated regularly using a 1-litre precision syringe. The spirometric manoeuvre was performed three times but was repeated if the difference between two maximal readings was >4%. The highest FEV1 and FVC measurements were used. We also measured weight and height and calculated body mass index (BMI) as weight/height2; overweight was defined as BMI ⩾25 kg/m2. Participants were classified as having a high level of physical activity if they were engaged in brisk physical activities (causing some sweating and breathlessness) at least 2–3 times a week for at least 20 minutes at a time (the approximate minimum level of activity which could enhance either fitness or health21). Current smokers were defined as smoking cigarettes daily for at least a year, former smokers if they had previously smoked cigarettes but had stopped for at least 1 year, and never smokers if they had neither currently nor previously smoked cigarettes daily for at least a year. Adult social class was based on highest education attained at 31 years (I = university degree, II = secondary or polytechnic school, III = vocational school, and IV = others, including unknown or no education after elementary school). We also noted any history of physician-diagnosed asthma and emphysema or chronic bronchitis.

Statistical analysis

A total of 6033 participants attended the clinical examination at age 31 years. Those with missing or inadequate spirometric findings (n = 153), those born at <37 weeks (n = 275) and women who were pregnant during the clinical assessment (n = 216) were excluded. The remaining 5390 participants (2684 men, 2706 women) were included in the analyses.

The results for men and women were analysed separately. Multiple linear regression was used to estimate the difference in respiratory function per 500 g higher birth weight (1SD of birth weight = 497 g) and per 1 kg higher weight gain during the first year (available for 2262 men and 2295 women; 1SD of weight gain during the first year = 1.1 kg). Covariates included gestational age at birth, adult height and adult weight, a history of acute respiratory infection or pneumonia in childhood, maternal smoking during pregnancy, parental social class at birth, and adult cigarette smoking, physical activity level and social class. As covariates we used gestational age and adult height and weight as continuous variables in the regression models. We also mutually adjusted for birth weight and weight gain during the first year. Mean FEV1 and FVC were calculated by tertile of birth weight stratified by tertile of weight gain during the first year or by adult smoking, physical activity or BMI.

Expected FEV1 was determined for men and women who were never smokers and without emphysema or chronic bronchitis using sex-specific regression with height as an explanatory variable and percentage predicted FEV1 ((actual FEV1/expected FEV1) ×100) was calculated. We also calculated the ratio of FEV1 to FVC. Interactions between birth weight and weight gain during the first year, adult smoking, adult physical activity or adult BMI were assessed by analysis of variance. BMI was used to define overweight and for assessing interaction with other covariates. In our analyses of the FEV1:FVC ratio, the covariates used in the regression models were similar to those used in our separate analyses for FEV1 and FVC. However, we only adjusted for gestational age, maternal smoking during pregnancy, adult weight and adult physical activity in the multivariate regression models for predicted FEV1. Two-sided p values were used with p<0.05 being considered statistically significant. Data were analysed using Stata V.8 statistical software (College Station, Texas, USA).

RESULTS

Baseline characteristics of study participants

Compared with the remaining cohort members born full term, the 5390 study participants had 80 g higher birth weight and 0.4 weeks longer gestational age at birth (both p<0.001) but did not differ significantly in weight gained during their first year (p>0.05). The characteristics of the study participants are shown in table 1 (see table S1 in the online supplement for characteristics by birth weight quintile). Mean (SD) birth weight was 3592 (512) g in men and 3467 (474) g in women; mean (SD) weight gain during the first year was 7.0 (1.1) kg in men and 6.5 (1.1) kg in women. Respective mean (SD) values for FEV1 in men and women were 4.54 (0.62) l and 3.41 (0.47) l, and for FVC were 5.48 (0.75) l and 4.02 (0.55) l.

Table 1

 Characteristics of men and women in the 1966 Northern Finland Birth Cohort study

Birth weight, weight gain at 1 year and respiratory function at age 31 years

Respiratory function (FEV1, FVC and % predicted FEV1) linearly increased across the whole range of birth weight quintile (p for trend <0.001) without any apparent threshold. Mean differences in respiratory function between top and bottom birth weight quintiles in men were 368 ml (FEV1) and 459 ml (FVC), and in women were 290 ml (FEV1) and 314 ml (FVC) (see table S1 in online supplement available at http://thorax.bmj.com/supplemental). These mean differences reduced to 169 ml (95% CI 95 to 242) for FEV1 and 180 ml (95% CI 95 to 266) for FVC in men, and to 141 ml (95% CI 84 to 198) for FEV1 and 115 ml (95% CI 49 to 180) for FVC in women after adjusting for gestational age, maternal smoking during pregnancy and adult factors (height, cigarette smoking, weight and physical activity). The mean FEV1:FVC ratio did not vary significantly across birth weight quintiles (p for trend = 0.56 in men and 0.31 in women) (see table S1 in online supplement). After adjusting for the aforementioned covariates, a significant increasing trend across birth weight quintiles was observed only among women (p = 0.047). The magnitude of the difference in the adjusted mean FEV1:FVC ratio between the top and lowest birth weight quintile was 0.4% (95% CI –0.5% to 1.3%) in men and 1.1% (95% CI 0.2% to 2.0%) in women. Adjusting for gestational age, maternal smoking during pregnancy and adult weight and physical activity, the difference in mean predicted FEV1 between the top and lowest birth weight quintile in men was 3.7% (95% CI 2.1% to 5.2%) and in women was 4.4% (95% CI 2.8% to 6.0%).

Both FEV1 and FVC were significantly higher for every 500 g higher birth weight (table 2), although the size of the coefficients was reduced by about half with adjustment for gestational age and adult height. The estimates remained significant with further adjustment for various potential confounders across the life course, even among relatively healthy men and women. Combining data for men and women and adjusting for sex, gestational age, maternal smoking during pregnancy and other adult factors, every 500 g higher birth weight was associated with a higher FEV1 of 53.1 ml (95% CI 38.4 to 67.7) and a higher FVC of 52.5 ml (95% CI 35.5 to 69.4). A significant association between birth weight and FEV1:FVC ratio was observed in women (but not in men) after adjusting for covariates. The estimated difference in predicted FEV1 for every 500 g higher birth weight was 1.3% (95% CI 0.8% to 1.8%) in men and 1.5% (95% CI 1.0% to 2.0%) in women after adjusting for gestational age at birth and adult factors (height, cigarette smoking, weight and physical activity). Adding a quadratic term for gestational age in the multivariate models used in table 2 did not materially alter the results.

Table 2

 Estimated difference in respiratory function, assessed at age 31 years, for every 500 g higher birth weight in 5390 men and women in the 1966 Northern Finland Birth Cohort study

Weight gain during first year was positively associated with lung function in men and women, with the regression coefficients increasing in magnitude when models were further adjusted for birth weight (table 3), although the confidence limits crossed the null association for FEV1 in men. Those in the lowest birth weight category who gained more weight in infancy tended to have higher FEV1 than those who gained less weight (fig 1; see fig S1 in online supplement available at http://thorax.bmj.com/supplemental for FVC results), although a statistically significant interaction between birth weight and weight gain during first year was only observed for FEV1 in women (p = 0.046). Women in the top birth weight tertile with higher weight gain during the first year tended to have lower lung function values.

Table 3

 Adjusted* regression of respiratory function (assessed at age 31 years) with birth weight and weight gain† during the first year in men and women in the 1966 Northern Finland Birth Cohort study

Figure 1

 Forced expiratory volume in 1 s (FEV1) in litres at age 31 years by tertiles of birth weight and weight gain during the first year in (A) men and (B) women in the 1966 Northern Finland Birth Cohort study. The figure shows mean values and 95% confidence limits. Values obtained from regression models and adjusted for gestational age at birth, maternal smoking during pregnancy and factors at 31 years: height, weight, cigarette smoking (never, former and current), and physical activity level (high versus low); p value for interaction between birth weight and weight gain during the first year was 0.88 in men and 0.04 in women.

A statistical interaction was observed between birth weight and sex for FVC (p = 0.007) but not for FEV1 (p = 0.11) or FEV1:FVC ratio (p = 0.16). Similarly, a statistical interaction was observed between weight gain at 1 year and sex for FVC (p = 0.001), weakly for FEV1 (p = 0.067) but not for FEV1:FVC ratio (p = 0.17).

Birth weight, adult characteristics and respiratory function at age 31 years

Higher FEV1 was noted with higher birth weight tertile across all categories of cigarette smoking, physical activity and BMI categories at age 31 years (fig 2; see fig S2 in online supplement available at http://thorax.bmj.com/supplemental for FVC results). Lowest values were observed among those in the bottom birth weight tertile who were smokers, had low physical activity level or were overweight. Participants with favourable profiles on these lifestyle variables but were at the lowest birth weight tertile had comparable, or even lower, FEV1 than those at the top birth weight tertile who were smokers, had lower physical activity level or were overweight. We did not observe any significant interaction between birth weight and these adult variables (p>0.05) except in smoking for FEV1 (p = 0.03 in men). The interactions between adult smoking and adult BMI for FEV1 and FVC in both men and women were not significant (all p>0.05).

Figure 2

 Forced expiratory volume in 1 second (FEV1) in litres in (A) men and (B) women at age 31 years by tertile of birth weight stratified by adult characteristics of men and women in the 1966 Northern Finland Birth Cohort study. The figure shows mean values and 95% confidence limits. Values obtained from regression models and adjusted for gestational age at birth, maternal smoking during pregnancy and factors at 31 years: height, weight, cigarette smoking (never, former and current) and physical activity level (high versus low) except for factor under consideration or weight for analysis using body mass index (weight/height2). Smokers were current smokers and non-smokers were never and former smokers combined. High physical activity level defined as participation in brisk activity of at least 20 minutes twice a week and low level if participation was less in duration and/or frequency per week. p for interactions: birth weight and smoking (men = 0.03, women = 0.31), birth weight and physical activity (men = 0.09, women = 0.41), and birth weight and body mass index (men = 0.54, women = 0.30).

DISCUSSION

Respiratory function, assessed by FEV1 and FVC at age 31 years, increased linearly across the whole range of birth weight in both men and women with no apparent threshold. Weight gain during the first year was positively associated with adult lung function independently of birth weight. These observations suggest that respiratory health in adulthood could be influenced by growth early in life.

The association between early life measures such as weight at birth and infancy and respiratory function measured 31 years later could simply reflect the effect of height, an important determinant of respiratory function22 as lower birth weight babies tend to be shorter in stature later in life,23 but the present results were independent of adult height. The associations were independent of gestational age at birth, maternal smoking during pregnancy and childhood respiratory infections as well as known asthma or emphysema or chronic bronchitis in adulthood. The findings remained significant even after taking into account adult smoking habit, level of physical activity and weight as well as social class at birth and in adulthood. Indeed, the magnitude of the reduction in lung function was greatest among those who had a lower birth weight and were current smokers, led a sedentary lifestyle or were overweight. Although spirometric assessment can be influenced by voluntary effort, it seems unlikely that there would be systematic differences in spirometric performance with respect to early life growth.

Earlier studies evaluating the association between birth weight and respiratory function have focused on highly selected participants or studied outcomes in childhood1–4 when lung function has not reached the maximum potential. Few studies have assessed the relation between birth weight and lung function in adulthood, and the results have been inconsistent. Some studies have shown no association between birth weight and adult lung function,7,9,12–14 while others have found a positive relationship either with both FEV1 and FVC5,6,10,11 or with FEV1 but not FVC.5 Consistent with other studies,5,6,8 we found no trend in the FEV1:FVC ratio across quintiles of birth weight, although we found a weak but significant association among women. This sex-related difference in the findings was due to the weaker association of birth weight with FVC than with FEV1 in women, whereas the associations of birth weight with both measures were of similar magnitude in men.

Previous studies were limited by small sample size,6,7,9–11,13 use of self-reported birth weight,14 retrospectively obtained perinatal information or reliance on the availability of birth weight data from historical records.5–8,11,12 Other limitations include loss to follow-up of participants,8,11 use of hospital-based populations9,10 and limited data for women5 or men.14 Our study was based on a large population-based cohort of men and women who were prospectively followed up from the fetal period to adulthood. Furthermore, our birth weight data were obtained immediately after birth, minimising errors associated with timing, inaccurate recall and rounding off of birth weight measurement.

These limitations could have important implications in determining the strength of the association between early growth and adult lung function. A meta-analysis of these studies suggested that 1 kg of birth weight was associated with an increase in FEV1 of 48 ml (95% CI 26 to 70) after adjusting for age, smoking and height.14 Using a similar regression model, a 1 kg change in birth weight in our cohort was associated with a difference in FEV1 of 96.1 ml (95% CI 55 to 137.2) in men and 80.0 ml (95% CI 47.0 to 113.2) in women (combined estimates for men and women after further adjustment for sex was 89.2 ml (95% CI 62.6 to 115.8)). Taking into account other factors through the life course suggests that these estimates might be slightly higher (table 2). The estimate in the meta-analysis may reflect non-random measurement errors which could have weakened the true association. Our findings suggest that the association between birth weight and adult lung function could be stronger than previously shown.

The effect of postnatal growth on adult lung function has been less well studied. It has been suggested that lower birth weight babies with higher postnatal weight gain may develop metabolic abnormalities and cardiovascular disease in adulthood.24 One study suggested that small babies who gained greater weight at 5–14 weeks had diminished infant lung function than those who gained less weight.25 In our cohort, postnatal weight gain among those in the lowest birth weight category was not associated with diminished adult lung function. Furthermore, anthropometric measures at birth and at 12 months among Chileans were unrelated to FEV1 measured in their late teens.26 Actual data were not presented in this paper, but we speculate that an age-related decline might heighten differences in lung function across the birth weight gradient. Alternatively, ethnicity might also play a role. In a non-Caucasian population, birth weight was reported to be unrelated to adult lung function.9

Pulmonary development runs in parallel with the stage of bodily development at birth.27,28 In humans, lung development continues postnatally with airway and alveolar formation and enlargement mainly continuing up to 2 years of age.28,29 As fetal life is a period of rapid growth, any stimulus or insult at this critical period of early life development could permanently alter or “programme” the structure and physiology of the respiratory system with possible long-term consequences.30 Lower birth weight could indicate the effect of an adverse intrauterine environment which retards growth in utero and consequently constrains growth of the airways and peripheral lung development. Since alveolar development continues into early infancy, impaired postnatal growth could also restrict further lung growth and differentiation.

The mechanism linking fetal growth retardation and impaired lung development is unclear. Maternal smoking during pregnancy is associated with lower birth weight,31 impaired lung function in infancy32 and childhood,33 and higher lung function decline in young adulthood.34 Although our findings were independent of maternal smoking during pregnancy, other factors such as maternal nutrition during pregnancy could play a role.29 In animals, impairment in airway development has accompanied intrauterine growth restriction due to undernutrition.35,36 Intrauterine growth restriction, which could also be due to excess fetal exposure to exogenous adrenocortical hormones,37 is associated with raised fetal cortisol levels.38 Prolonged early life exposure to glucocorticoids could have adverse affects on lung morphometry and alveolarisation.39 Fetal growth retardation in itself may restrict lung distension, an important physical factor known to stimulate fetal lung growth.40 Lower birth weight has been associated with a lower proportion of lean mass41 and lower muscular strength,42 possibly affecting the muscular component of ventilation. As low birth weight has been associated with diminished lung function in infancy4 and in childhood,1–3 and pulmonary function has been shown to track in childhood and adolescence to adulthood,43 it is plausible that the reduced adult lung function in lower birth weight babies reflects their failure to achieve maximum adult ventilatory capacity. Although our cohort is still mainly too young to develop important clinical outcomes such as chronic obstructive pulmonary disease, diminished lung function in young adulthood could render them at higher risk of developing chronic obstructive airway disease later in life.5

Our study has certain limitations. We did not assess lung function serially over time, although a single measurement of pulmonary function in adulthood has consistently been shown to predict important health outcomes in different populations.15,16 Further, the relatively increased age-related decline in pulmonary function is normally observed in the late 30s, so our estimates are probably more stable and less affected by these rapid changes.44 However, we may not be able to assess changes over time separately for FEV1 and FVC which might have implications in interpreting the age-related or sex-specific decline in the FEV1:FVC ratio.44 Reversibility of airflow limitation was not examined, but we have previously shown that birth weight is unrelated to asthma or skin atopy.45 We also cannot rule out a common underlying genetic explanation for fetal growth retardation and reduced adult lung function. On the other hand, an important strength of the study is that we were able to include prospectively collected data on potential confounders and mediating factors operating throughout the life course.

In conclusion, babies with lower birth weight and poor infant growth may be at a higher risk for developing impaired adult pulmonary function. Our findings suggest that impaired respiratory function may be preventable or modifiable through the life course by targeting better maternal health during pregnancy, improved nutrition in infancy and adopting a healthy lifestyle in adulthood.

Acknowledgments

The authors thank the participants and staff for their continued cooperation with the study. They also acknowledge the database management support of Mr Markku Koiranen (University of Oulu) and Ms Ulla Sovio (Imperial College London), and statistical advice from Mr Jari Jokelainen (University of Oulu), Professor Nicholas Day (University of Cambridge) and Dr Anne-Helen Harding (University of Cambridge).

REFERENCES

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Footnotes

  • Published Online First 13 November 2006

  • The 1966 Northern Finland Birth Cohort study has been supported by programme grants from the Academy of Finland, the University of Oulu and the University Hospital Oulu. Additional grants were received from the European Commission (Quality of Life and Management of Living Resources Programme, contract number QLG1-CT-2000-01643) for data collection. Funding agencies were not involved in the study design, analysis and data interpretation, writing of the manuscript, and the decision to submit the paper for publication.

  • Competing interests: None declared

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