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β2 adrenoceptor polymorphisms (ADRB2 gene) are not strongly associated with asthma incidence or prevalence
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  1. M Pagaria
  1. Intermediate Trainee Intensive Care, Gloucestershire Royal Hospital, Gloucester, UK; dr_pagaria@yahoo.co.uk

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    ▴ Hall IP, Blakey JD, Al Balushi KA, et al. β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet2006;368:771–79.
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    The aim of this study was to analyse any potential correlation between β2 adrenoceptor (ADRB2) polymorphism and asthma risk and prognosis. The ADRB2 gene contains polymorphic variants with high minor allele frequencies in the white population. The three coding regions, Arg16Gly, Gln27Glu and Thr164Ile, are shown to be functionally relevant. Previous meta analyses looking into the correlation between the genetic polymorphism and asthma risk have …

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