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Thorax 2006;61:375 doi:10.1136/thx.2006.la0200
  • Miscellaneous

Vitamin D3 and response to glucocorticoids in steroid resistant asthmatics

  1. S Kon
  1. Clinical Fellow, University College Hospital, London, UK; Samanthakon@aol.com

    ▴ Xystrakis E, Kusumakar S, Boswell S, et al. Reversing the defective induction of IL-10 secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest2006;116:146–55

    This study showed that human IL-10 secreting regulatory T cells (Tregs) inhibit cytokine production from allergen specific Th2 cells in an IL-10 dependent manner. They therefore have the capacity to inhibit the immune response implicated in the pathogenesis of asthma. In steroid resistant asthmatics the failure of T …

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