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Letters to the editor
Per lesion analysis is misleading
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  1. K-C Chang,
  2. C-C Leung,
  3. C-M Tam
  1. TB and Chest Service, Centre for Health Protection, Department of Health, Hong Kong
  1. Correspondence to:
    Dr K-C Chang
    Yaumatei Chest Clinic, Yaumatei Jockey Club Polyclinic, 145 Battery Street, Kowloon, Hong Kong; ymtcc{at}dh.gov.hk

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    We read with interest the randomised controlled trial by Häußinger and co-workers1 which compared autofluorescence bronchoscopy (AFB) plus white light bronchoscopy (WLB) with WLB alone for detecting precancerous lesions. The authors stratified their patients into four different risk groups before randomisation. They also excluded from analysis biopsy samples taken from or next to visible tumours. Their major findings suggested that WLB plus AFB was significantly superior to WLB alone for detecting precancerous lesions.

    While we appreciate the clinical significance of their major findings, we found the per lesion analysis adopted in the paper misleading for evaluating the sensitivity, …

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