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Inhaled hypertonic saline, mechanisms, and improved lung function in cystic fibrosis
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  1. A Gondker
  1. Senior House Officer, Kettering General Hospital, Kettering, UK; anjaligondker@hotmail.com

https://doi.org/10.1136/thx.2006.la0199

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    ▴ Donaldson SH, Bennett WD, Zeman KL, et al. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med2006;354:241–50
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    This study compared the effect of inhaled hypertonic saline on 24 patients with cystic fibrosis over a 28 day period. Subjects were assigned to two groups receiving pretreatment with either amiloride or placebo before saline inhalation. One hour mucus clearance rates, lung function tests, and quality …

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