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Inhaled corticosteroids and long term outcome in adults with asthma
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  1. P J F M Merkus,
  2. J C de Jongste
  1. Sophia Children’s Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands
  1. Correspondence to:
    Dr P J F M Merkus
    Sophia Children’s Hospital, Erasmus University Medical Centre, Rotterdam 3015 GJ, The Netherlands; p.j.f.m.merkus{at}erasmusmc.nl

https://doi.org/10.1136/thx.2006.062810

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    The concept that treatment with inhaled corticosteroids (ICS) may improve long term lung function by reversing or minimising the effects of airway remodelling remains an attractive one but, until now, unproven. It is therefore with much interest that we read the publications of two observational studies by Lange et al1 and by Dijkstra et al.2 Both groups of authors hypothesised that asthmatic individuals continuously treated with ICS would have a less pronounced decline in forced expiratory volume in 1 second (FEV1) than those not treated with …

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