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Thorax 60:730-734 doi:10.1136/thx.2004.039180
  • Asthma

Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma

Table 3

 Mean difference (95% CI) for all secondary outcome measures between the group receiving added salmeterol and the group receiving increased dose of ICS

Outcome measure Difference in original units† Inconsistency measures
Fixed effects Random effects
†Mean difference represents the mean outcome measure for the group receiving added salmeterol minus the mean outcome measure for the group receiving increased dose of inhaled corticosteroid.
Morning PEF (l/min) 23 (19 to 28) 23 (15 to 30) 63.7 (25.5 to 82.3)
Evening PEF (l/min) 19 (15 to 23) 19 (13 to 24) 29.9 (0.00 to 82.3)
FEV1 (l) 0.12 (0.09 to 0.15) 0.12 (0.06 to 0.18) 71.0 (36.7 to 86.7)
Night awakenings (no/week) −0.03 (0.00 to −0.07) −0.03 (0.01 to −0.07) 20.5 (0.00 to 65.1)
Day time β agonist use (puffs/day) −0.58 (−0.44 to −0.72) −0.60 (−0.35 to −0.84) 70.3 (30.5 to 87.3)
Night time β agonist use (puffs/night) −0.08 (−0.02 to −0.13) −0.08 (−0.00 to −0.16) 58.0 (0.00 to 83.0)

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