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Neutrophilic inflammation in childhood bronchial asthma
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  1. K Yasui1,
  2. N Kobayashi1,
  3. T Yamazaki1,
  4. K Koike1,
  5. K Fukushima2,
  6. S Taniuchi3,
  7. Y Kobayashi3
  1. 1Department of Paediatrics, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
  2. 2Department of Hematology and Oncology, Nagano Children’s Hospital, Toyoshina 399-8288, Japan
  3. 3Department of Paediatrics, Kansai Medical University, Moriguchi 570-8506, Japan
  1. Correspondence to:
    Dr K Yasui
    Department of Pediatrics, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan; k-yasuihsp.md.shinshu-u.ac.jp

https://doi.org/10.1136/thx.2005.043075

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    Although there is increasing evidence that neutrophilic inflammation is involved in enhanced bronchial reactivity and exacerbation of bronchial asthma,1,2 the definitive role of neutrophil mediated inflammation in the pathophysiology has not been fully established. To investigate this further, we performed a historical cohort study of 64 children with primary autoimmune neutropenia (AIN) and compared the incidence of asthma with a control group. The study was approved by the Human Research Committee of Shinshu University.

    Between January 1997 and December 2000, 64 patients (31 boys and 33 girls) of mean (SD) age 6.1 (1.9) years (range 4.8–10.3) were recruited from our hospitals (table 1). They were followed up for at least 3 years. All were diagnosed with AIN by …

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