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  • Increased disease activity in a patient with sarcoidosis after high dose interleukin 2 treatment for metastatic renal cancer

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Case Report
Increased disease activity in a patient with sarcoidosis after high dose interleukin 2 treatment for metastatic renal cancer
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  1. T F Logan1,
  2. E S Bensadoun2
  1. 1Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA
  2. 2Division of Pulmonary and Critical Care Medicine, University of Kentucky, Lexington, KY, USA
  1. Correspondence to:
    Dr E S Bensadoun
    University of Kentucky, Division of Pulmonary and Critical Care Medicine, 740 South Limestone, K528 Kentucky Clinic, Lexington, KY 40536-0284, USA; ebens0uky.edu

Abstract

Sarcoidosis is a disease of unknown aetiology in which cytokines such as interleukin 2 (IL-2) are thought to play an important role. We present the case history of a 48 year old man with sarcoidosis who received treatment with high dose IL-2 for metastatic renal cell cancer, following which he developed hypercalcaemia characterised by a raised level of 1,25-dihydroxyvitamin D (1,25-(OH)2-D3), a finding consistent with sarcoidosis associated hypercalcaemia. The increased activity in his sarcoidosis following IL-2 treatment provides direct supportive evidence for the role of IL-2 in the pathogenesis of sarcoidosis.

  • sarcoidosis
  • hypercalcaemia
  • interleukin 2
  • renal carcinoma
  • hydroxychloroquine

https://doi.org/10.1136/thx.2004.024018

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    Footnotes

    • ↵* Conversion factors for SI units: creatinine: ×88.4 μmol/l; albumin: ×10 g/l; calcium (total): ×0.25 mmol/l; calcium (ionised): ×0.25 mmol/l; 1,25-(OH)2-D3: ×2.40 pmol/l.