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Thorax 2005;60:287 doi:10.1136/thx.2004.la0142
  • Miscellaneous

Evidence for a genetic susceptibility to lung carcinoma

  1. C Carlin
  1. Clinical Research Fellow, Scottish Pulmonary Vascular Unit, Western Infirmary, Glasgow, UK; ccarlin@tiscali.co.uk

    ▴ Jonsson S, Thorsteinsdottir U, Gudbjartsson DF, et al. Familial risk of lung carcinoma in the Icelandic population. JAMA2004;292:2977–83

    Previous studies of the genetic epidemiology of lung cancer have suggested a modest (twofold) increased risk associated with a family history of lung cancer. It has been unclear whether the increased risk observed reflected genetic factors specific to lung cancer, genetic modifiers of nicotine addiction (leading to increased tobacco …

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