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A 75 year old woman was referred to our hospital for suspected sleep apnoea. Her medical history mentioned arterial hypertension and paroxysmal atrial fibrillation (AF). Polysomnography revealed obstructive sleep apnoea (OSA). During one phase of OSA the heart rate, determined by signals derived from pulse oximetry, showed a sharp rise in frequency (fig 1, left). Simultaneously recorded electrocardiography (ECG) indicated AF (fig 2A). The onset of AF was preceded by a long apnoeic event (48 s) with marked oxygen desaturation (Sao2 67%). After a period without apnoeas, spontaneous reversal to sinus rhythm occurred (fig 1, right; fig 2B).
OSA has been reported to be associated with an increased risk of recurrence of AF after primarily successful electrical cardioversion,1 and sleep disordered breathing has been found to be very common in patients with AF.2 The present report gives the first direct evidence that OSA might trigger episodes of AF. Although we cannot definitively exclude the possibility that our observations are coincidental, we suggest a causal association between OSA and the onset of AF. Since AF occurred immediately after a long lasting apnoea with severe oxygen desaturation, its most likely trigger was OSA associated hypoxaemia. Other pathogenetic mechanisms include intrathoracic pressure swings and sympathetic activation. The fact that the AF stopped after a phase of undisturbed breathing also suggests that the heart rhythm disorder was induced by OSA. We presume that the absence of these stimuli led to atrial electrical stabilisation and the return to sinus rhythm.
Conflicts of interest: none.
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