The renin-angiotensin system: a potential therapeutic target in ARDS? | Thorax

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The renin-angiotensin system: a potential therapeutic target in ARDS?

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J Elder

LAT Respiratory Medicine, Belfast City Hospital, Northern Ireland, UK; jenniferhelder@hotmail.com

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▴ Imai Y, Kuba K, Rao S, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature2005;436:112–6

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This paper reports a critical role of the renin-angiotensin system (RAS) in the pathogenesis of acute lung injury (ALI) in the mouse. Angiotensin converting enzyme (ACE) and its counter-regulatory homologue ACE2 determine the levels of angiotensin II (ATII) within the lung. By a series of logical stepwise experiments, manipulating …