Table 3
Effect of salmeterol on dyspnoea and operational lung volumes during treadmill exercise
| Placebo | Salmeterol | Mean difference (95% CI) | p value | |
|---|---|---|---|---|
| Values are mean (SD) and mean treatment differences with 95% CI except for resting Borg scores where values are median (25th, 75th interquartile range). | ||||
| Borg = modified Borg dyspnoea scale; Δ = change from rest to end isotime; IC = inspiratory capacity; DH = dynamic hyperinflation; EELV = end expiratory lung volume; EILV = end inspiratory lung volume; TLC = total lung capacity; IRV = inspiratory reserve volume; ISO = isotime | ||||
| *Significant period × treatment interaction. | ||||
| Rest Borg | 0.0 (0.0, 0.5) | 0.0 (0.0, 0.5) | 0.03 (−0.17 to 0.24) | 0.75 |
| ISO Borg | 4.62 (1.09) | 3.78 (1.14) | −0.84 (−1.54 to −0.14) | 0.02 |
| ΔBorg | 4.34 (1.22) | 3.47 (1.07) | −0.87 (−1.55 to −0.20) | 0.01 |
| Rest IC (l) | 1.32 (0.43) | 1.48 (0.52) | 0.16 (0.02 to 0.32) | 0.03* |
| ISO IC (l) | 0.98 (0.44) | 1.27 (0.51) | 0.29 (0.11 to 0.44) | 0.002 |
| DH (ΔIC) (l) | 0.33 (0.20) | 0.22 (0.15) | −0.11 (−0.18 to −0.04) | 0.002 |
| Rest EELV/TLC (%) | 80.0 (4.0) | 76.6 (7.7) | −3.4 (−6.3 to −0.6) | 0.02 |
| ISO EELV/TLC (%) | 85.3 (5.1) | 80.3 (6.9) | −5.0 (−8.0 to −2.2) | 0.002 |
| Δ EELV/TLC (%) | 5.3 (3.3) | 3.7 (2.6) | −1.6 (−2.7 to −0.7) | 0.003 |
| Rest EILV/TLC (%) | 90.2 (4.2) | 87.1 (6.0) | −3.1 (−5.6 to −0.6) | 0.02 |
| ISO EILV/TLC (%) | 98.2 (5.7) | 93.5 (5.3) | −4.7 (−7.6 to −1.8) | 0.004 |
| Δ EILV/TLC (%) | 8.0 (4.3) | 6.4 (4.5) | −1.6 (−3.3 to 0.1) | 0.07 |
| ISO Sao2 (%) | 87.0 (6.7) | 87.8 (6.4) | 0.8 (−0.4 to 1.9) | 0.18 |
| Endurance time (s) | 333 (151) | 347 (180) | 14 (−23.9 to 52.0) | 0.44 |
