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Thorax 59:380 doi:10.1136/thx.2004.la0086
  • Miscellaneous

Abnormalities of fatty acid metabolism in CF

  1. S Bailey
  1. Clinical Fellow, The Manchester Adult Cystic Fibrosis Centre, Wythenshawe Hospital, Manchester, UK; Simon.Bailey@smuht.nwest.nhs.uk

    ▴ Freedman SD, Blanco PG, Zaman MM, et al. Association of cystic fibrosis with abnormalities in fatty acid metabolism. N Engl J Med2004;350:560–9

    This study found low tissue levels of the fatty acid docosahexaenoic acid (DA) and a raised ratio of arachidonic acid (AA) to DA in patients with cystic fibrosis (CF) compared with healthy controls in nasal and rectal biopsy specimens (p<0.001 and p = 0.009 for the ratios, respectively). In cells from …

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