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  • Doubling the dose of inhaled corticosteroid for asthma exacerbations does not decrease subsequent use of systemic steroids

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Doubling the dose of inhaled corticosteroid for asthma exacerbations does not decrease subsequent use of systemic steroids
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  1. M Soth
  1. Respirology Resident, McMaster University, Hamilton, Canada; msoth@idirect.com

https://doi.org/10.1136/thx.2004.la0083

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    ▴ Harrison TW, Oborne J, Newton S, et al. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet2004;363:271–5
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    This blinded trial with concealed randomisation compared doubling the dose of inhaled corticosteroid for 14 days with continuing the same dose when asthma symptoms or peak flow worsened in patients monitoring themselves daily at home. The 390 patients enrolled had been given oral corticosteroid or transiently doubled their inhaled corticosteroid dose in …

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