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Ambroxol and reduction of COPD exacerbations
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  1. W R Perera
  1. Clinical Research Fellow, St Bartholomew’s Hospital, London, UK; Wayomiperera@aol.com

https://doi.org/10.1136/thx.2004.la0081

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    ▴ Malerba M, Ponticiello A, Radaeli A, et al. Effect of twelve months therapy with oral ambroxol in preventing exacerbations in patients with COPD. Double-blind, randomized, multicenter, placebo-controlled study (the AMETHIST trial). Pulm Pharmacol Ther2004;17:27–34
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    This prospective, randomised, double blind, multicentre, placebo controlled study examined the effect of ambroxol (an agent stimulating mucociliary clearance and surfactant production) in preventing acute exacerbations of COPD. 242 patients with GOLD stage IIa COPD, a …

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