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Thorax 59:164-169 doi:10.1136/thorax.2003.006494
  • Review series

α1-Antitrypsin deficiency · 1: Epidemiology of α1-antitrypsin deficiency

Table 2

Relationship between expected and diagnosed cases of AAT deficiency (Pi ZZ + Pi SZ) in selected countries

Country AAT deficiency expected AAT deficiency diagnosed
Expected cases are based on de Serres13 and Martin et al26; diagnosed cases are from Alpha One International Registry (AIR) central database (updated April 2003, courtesy of Claes-Göran Löfdahl, Eeva Piitulainen, Ragnar Alm). Individuals with AAT deficiency in the AIR database were recruited since 1999 in a prospective fashion.
Canada 42372 144
Italy 46068 100
The Netherlands 9790 136
New Zealand/Australia 33707 93
Spain 86899 90
Sweden 6717 181
UK 79456 324
Total 305009 1068

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