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Thorax 59:1052-1056 doi:10.1136/thx.2004.022806
  • Environmental exposure

Effects of asbestos and smoking on the levels and rates of change of lung function in a crocidolite exposed cohort in Western Australia

Table 5

 Predictors of change of lung function in a cohort of asbestos exposed subjects according to the linear mixed model

FEV1 (ml) FVC (ml) FEV1/FVC %
Estimate (SE) p value Estimate (SE) p value Estimate (SE) p value
All variables were included in the model. Age was centred to 56 years and height to 165 cm.
Follow up (years) −24 (2) <0.001 −39 (3) <0.001 0.17 (0.05) 0.001
Follow up* cumulative asbestos −0.08 (0.02) 0.001 −0.10 (0.03) 0.001
Follow up* radiographic asbestosis −13 (2) <0.001 −20 (3) <0.001
Follow up* current smokers −13 (2) <0.001 −3.3 (3.3) 0.31 −0.41 (0.05) <0.001
Follow up* ex-smokers −1.0 (2.0) 0.62 3.8 (2.5) 0.13 −0.13 (0.04) 0.001

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