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Thorax 2004;59:1051 doi:10.1136/thx.2004.la0126
  • Miscellaneous

The eosinophil in airway remodelling and hyperresponsiveness in asthma: participant or bystander?

  1. M Soth
  1. Respirology Resident, McMaster University, Hamilton, Canada; msoth@idirect.com

    ▴ Lee JJ, Dimina D, Macias MP, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science2004;305:1773–6

    ▴ Humbles AA, Lloyd CM, McMillan SJ, et al. A critical role for eosinophils in allergic airways remodelling. Science2004;305:1776–9

    While the presence of eosinophils in asthma has long been recognised, it remains unclear whether they are directly involved in the pathogenesis of asthma or are merely an epiphenomenon. Both Lee et al and Humbles et al used an acute inhaled allergen challenge with ovalbumin as a model of asthma. Lee et …

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