Which smokers will acquire COPD? | Thorax

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Which smokers will acquire COPD?

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M Johnson

Specialist Registrar, Ayr Hospital, Ayr, UK; mkjguard-dispo2@yahoo.co.uk

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▴ Celedón JC, Lange C, Raby BA, et al. The transforming growth factor-β1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet2004;13:1649–56

OpenUrl Abstract/FREE Full Text

This study uses two sequential approaches to identify genetic determinants of COPD in the absence of α₁-antitrypsin deficiency. Firstly, using subjects from the Boston Early-Onset COPD Study (FEV₁ ⩽40% predicted, age <53 years, not α₁-antitrypsin deficient), linkage analysis …