Table 2
Studies reporting FEV1 (% predicted) in α1-antitrypsin PI MZ heterozygotes
| Author | Year | Country | Study population | No. >PI MM |
Mean FEV1 >(% predicted) |
No. >PI MZ |
Mean FEV1 >(% predicted) |
Adjustment for smoking |
|---|---|---|---|---|---|---|---|---|
| PI, protease inhibitor; FEV1, forced expiratory volume in 1 second. | ||||||||
| Webb32 | 1973 | USA | Consecutive patients at an early disease detection unit | 395 | 92.0 | 18 | 102.0 | None |
| Hall21 | 1976 | USA | Matched pairs identified from patients at an early disease detection unit | 15 | 107.0 | 15 | 110.0 | Restricted to non-smokers |
| Morse28 | 1977 | USA | Population sample of Caucasians in Tuscon, Arizona | 2637 | 96.0 | 88 | 94.5 | None |
| Girard19 | 1978 | France | Matched pairs from a population sample of men in Nancy | 24 | 92.0 | 24 | 91.7 | Matched on smoking status |
| Eriksson16 | 1985 | Sweden | Matched pairs from a random sample of 56 year old men in Malmo | 14 | 99.0 (smokers) | 14 | 96.0 (smokers) | Stratified by smoking status |
| 4 | 111.0 (ex) | 6 | 105.0 (ex) | |||||
| 13 | 105.0 (non) | 12 | 104.0 (non) | |||||
| Horne22 | 1986 | Canada | Matched pairs of male grain workers in Saskatchewan | 28 | 104.0 | 28 | 94.0 | Matched on smoking status |
| Dahl15 | 2002 | Denmark | Population sample in Copenhagen (baseline data from longitudinal study) | 7037 | 90.0 | 451 | 91.0 | Not for FEV1 data |
