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Thorax 58:752-756 doi:10.1136/thorax.58.9.752
  • Chronic obstructive pulmonary disease

Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I

Table 3

Correlations between quadriceps peak torque, pulmonary function, and systemic levels of inflammatory and anabolic markers

Hospitalised COPD patients, day 3 Clinically stable COPD patients Healthy elderly subjects
*p=0.05; †p=0.03; ‡p=0.06; §p=0.02; ¶p=0.001.
FEV1=forced expiratory volume in 1 second; Tlco=carbon monoxide transfer factor; IL-6=interleukin 6; CXCL8=interleukin 8; IGF-I=insulin-like growth factor I.
Age (years) −0.34* −0.84¶ −0.61‡
FEV1 (l) 0.36† 0.78¶ 0.22
Tlco (mmol/kPa/min) 0.64¶ 0.80¶ –
Log IL-6 −0.38† 0.04 −0.16
Log CXCL8 −0.53¶ −0.57* −0.08
Log IGF-I 0.41§ 0.60† 0.64*

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