Article Text


Self-management of asthma in general practice
  1. J C van der Wouden1,
  2. R D W van Bentveld1,
  3. B Fu1,
  4. K S ter Meulen1,
  5. P A Muller1
  1. 1Department of General Practice, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands; j.vanderwouden{at}
  1. B P A Thoonen2,
  2. T R J Schermer2,
  3. C van Weel2
  1. 2University Medical Centre, Nijmegen, The Netherlands; b.thoonen{at}

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We welcome the paper by Thoonen and colleagues on self-management of asthma in general practice1 as we firmly believe that self-management of chronic diseases is a promising area for innovation in general practice.

We wondered whether differential withdrawals—specifically, the difference between groups in the number of patients for whom successfully treated weeks could be calculated—may have affected the outcomes. As reported, 92% of the patients in the usual care (UC) group provided data for this primary outcome compared with 85% of the self-management (SM) group. The mean percentage of successfully treated weeks was 72% and 78% for the UC and SM groups, respectively, a difference reported to be statistically significant. As we do not expect that these specific outcomes were analysed on an intention to treat basis, non-random withdrawals might have biased the findings—for example, when most patients who withdrew from the SM group did so because they were not able to comply with the SM programme and their asthma was badly controlled, this would affect the outcomes, inflating the differences in favour of the SM group.


Authors’ reply

In their letter van der Wouden and colleagues question the issue of selective withdrawal of subjects from the two study groups which may have had consequences for the validity of our conclusions. As a possible source of bias in calculating successfully treated weeks this may be an important issue which was not discussed in depth in our original paper.

To address this question we performed an additional analysis of the study records of all subjects excluded from the calculation of the successfully treated weeks. We divided all these subjects into two categories: (1) those excluded from the calculation because of side effects to inhaled steroids, poor asthma control, referral to a pulmonary physician, or non-compliance with the study protocol (categorised as “unable to comply”), and (2) subjects excluded because of a change of address or GP, pregnancy, or unknown reasons (categorised as “other reasons”). The number of subjects in the “unable to comply” subgroup was four out of 15 in the self-management group (4% of all self-management subjects) and five out of eight in the usual care group (5% of all usual care subjects). The number of withdrawals for asthma related reasons (including poor asthma control) was therefore relatively small in both study groups and was, in fact, relatively higher in the usual care group. We therefore believe that the impact on the number of successfully treated weeks must have been very limited and, if present at all, was in favour of the usual care group rather than the self-management group.

We conclude that, even if there were differences in the withdrawals between the two groups, this does not change our conclusion that self-management of asthma is at least equally as effective as the asthma treatment usually provided in Dutch primary care. This conclusion supports the view of van der Wouden and colleagues that self-management of asthma is a promising innovation in general practice.

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