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Anti-CD44 antibodies decrease airway inflammation and hyperresponsiveness in a murine model of allergic disease
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  1. K Ryanna
  1. St Richard’s Hospital, Chichester, UK, kryanna@hotmail.com

https://doi.org/10.1136/thorax.58.8.679

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    ▴ Katoh S, Matsumoto N, Kawakita K, et al. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. J Clin Invest2003;111:1563–70
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    This study investigates the effects of anti-CD44 murine antibodies on allergic airway inflammation induced by transnasal instillation of purified Ascaris suum (Asc) antigen. Two antibodies were used—one that directly blocks hyaluronic acid binding to cells expressing CD44, and one …

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